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   A support group for owners of dogs with GME (Granulomatous Meningoencephalomyelitis) or NME (Necrotizing Meningoencephalitis)
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Welcome to gmedogs forum

This forum was created as a support group for owners of dogs with GME (Granulomatous Meningoencephalomyelitis) or NME (Necrotizing Meningoencephalitis). The board is a place to share whatever you want with others who know what you are going through.
As a guest, you can read all the posts, but you will need to register to post something of your own.
I hope you find comfort and support in this group. Despite this disease's grim prognosis, new treatments have given hope to many dogs out there.


**This forum is Not Intended for and Does Not Give Veterinary Advice. Any articles or posts by members are intended for general information purposes only. Nothing here should be considered "veterinary advice", which can only be given to you by your own veterinarian or other professional. Some information you read on this site may be inappropriate for your own situation, or you may misinterpret something in a way that could be distressing or harmful to your pet. You should ALWAYS consult with a veterinarian before giving your pet any medications, herbal or otherwise, or before trying any form of treatment!!
This site is wholly owned and operated by non-veterinarians. Any information contained in this forum is from member postings only. This site is not intended for veterinary evaluation, diagnosis, or treatment purposes.**


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 Post subject: What are the symptoms?
PostPosted: Mon Jan 18, 2010 9:26 pm 
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For GME and NME, clinical signs are variable and reflect the location of the lesion(s).

If GME affects the forebrain, clinical signs could involve:

Blindness
Seizures
Altered mental status
Pacing
Circling
Head pressing
Stumbling with a nearly normal gait



If GME affects the hindbrain (brainstem +/- cerebellum), clinical signs may include:


Falling
Rolling
Inability to blink
Facial paralysis
Voice change
Mental depression
Tremors
Spastic gait and broad based stance



Spinal cord involvement of GME may include such signs as:


Fever
Spinal pain
Weakness or paralysis in one, two, or all four legs


The signs of GME in dogs can also vary with the form of GME. The ocular form of GME is characterized by acute loss of vision with dilated, unresponsive pupils. Multifocal GME is characterized by acute onset and rapid progression of CNS dysfunction, whereas dogs with focal GME tend to have a more insidious onset and slower progression of clinical signs. Whether alone (focal GME) or in combination (multifocal GME), seizures, cerebellovestibular dysfunction, and cervical hyperesthesia are common features of GME. Isolated spinal cord dysfunction and optic neuritis are relatively uncommon clinical presentations of GME.

With NE (including NME and NLE), seizure activity is frequent. In NME, the onset and progression of clinical signs of neurologic dysfunction may be acute (disease course of 2 weeks or less) or chronic (disease course of 4-6 months). Clinical signs of forebrain dysfunction (seizures, circling, obtundation, visual deficits with normal PLRs, head-pressing, etc.) predominate. Neck pain is also common and may be due to the meningitis and/or the forebrain disease.

Yorkshire Terriers with NLE typically experience a chronic, progressive worsening of neurologic dysfunction over several months. In addition to clinical signs of forebrain dysfunction and neck pain, Yorkshire Terriers with NLE often display clinical signs of brain stem dysfunction (e.g., central vestibular disease, depression of consciousness, limb weakness, and cranial nerve deficits).

In one report, it was found that dogs with NE tend to have clinical onset of disease most often during the summer months, between May and September.

Sources:

"Granulomatous Meningoencephalomyelitis (GME)." By Dr. John McDonnell. http://www.petplace.com/dogs/granulomat ... page1.aspx

Merck Vet Manual. http://www.merckvetmanual.com/mvm/index ... 101600.htm

A Practical Guide to Canine & Feline Neurology. Second Edition. By Curtis W. Dewey.


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